Treatment Guide
If you've been researching Korean skin care, you've probably noticed the same names keep appearing: Rejuran, Juvelook, exosome therapy, Innotox. They are widely used in Korean dermatology clinics, but they are not approved by the US Food and Drug Administration, so you won't find them at clinics in the United States. This guide explains what each treatment is, how it is regulated, and what to ask a licensed dermatologist before deciding whether any of them is right for you.
Rejuran is a polynucleotide (PN) injection derived from salmon DNA, part of the family of treatments often labelled PDRN. It is designed to support the skin's own repair processes. Unlike fillers that add volume, Rejuran aims to improve the quality of the skin itself, such as texture, elasticity, fine lines and hydration. It's considered a foundational treatment in Korean dermatology, often described as "skin rehabilitation" rather than cosmetic correction.
Rejuran is approved by Korea's Ministry of Food and Drug Safety and has been widely used there since 2014. Polynucleotide injectables have not been approved by the FDA, so they are not offered by US clinics. Because Rejuran is made from salmon DNA, tell your doctor about any fish allergy.
Clinics usually suggest 2 to 3 sessions, 3 to 4 weeks apart. Any change is gradual rather than immediate, and results vary from person to person. Small raised bumps at the injection points usually settle within a day or so.
Juvelook is a Korean-developed injectable that combines hyaluronic acid with poly-D,L-lactic acid (PDLLA) microspheres. The HA provides immediate hydration while the PDLLA microspheres dissolve slowly over months, continuously stimulating new collagen. Most standard fillers do one or the other. Juvelook is designed to do both at once, for overall skin quality rather than targeted volume correction.
Juvelook is approved by Korea's Ministry of Food and Drug Safety and CE-marked in Europe. It is not FDA-approved and is not currently offered in North America.
Some hydration is visible soon after treatment, while collagen stimulation develops gradually over 3 to 6 months. Results vary, and your doctor will advise on the number of sessions.
Exosomes are nano-sized vesicles packed with growth factors, peptides, and cell-signalling proteins. In Korean clinics, exosome serums are often applied to the skin straight after microneedling or laser treatments, with the aim of supporting healing and calming redness.
No exosome product is FDA-approved, and the FDA treats applying them after microneedling as using an unapproved drug. Evidence is still developing and products vary, so ask your doctor what the product is, where it comes from, and what it is expected to do.
Usually offered as an add-on to another treatment on the same day. How much difference it makes varies, and your doctor can tell you whether it suits your skin.
Innotox is a liquid form of botulinum toxin type A made by the Korean company Medytox. Conventional toxins such as Botox and Dysport arrive as a freeze-dried powder that a nurse mixes with saline right before your appointment. Innotox comes pre-mixed in a standardized solution, which practitioners like for consistent dosing from one vial to the next. It is used the same way as any type A toxin, softening forehead lines, frown lines, and crow's feet, along with jaw slimming and the light micro-dosing technique often called skin botox that is popular in Seoul.
Innotox has been approved by Korea's Ministry of Food and Drug Safety since 2013. It has not been submitted to the FDA, so US clinics use other type A toxins such as Botox, Dysport, Xeomin, Jeuveau and Daxxify instead.
Effects typically begin within a few days, peak at about two weeks and last roughly three to four months, similar to other type A toxins.
Treatments that are not approved where you live deserve extra care. A few things to do first:
Seoul has many dermatology clinics, especially in the Gangnam and Apgujeong districts, and they vary widely. For visitors, the hard parts are choosing a clinic you can trust, communicating clearly, and fitting treatment and recovery into a trip.
That is where Luxe Beauty Trip helps. We connect you with vetted clinics led by board-certified dermatologists, where a licensed doctor assesses you and recommends your options, and we plan your journey around your appointments and recovery. We are a travel planning service, not a medical provider, and all treatment decisions are made between you and your doctor.
On a free discovery call, we'll talk through your goals, your timing and how we would shape your journey. Treatment decisions are always made with the clinic's doctor.
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